Scientific Program
THE FUTURE OF REDOX BIOLOGY
SIENA 17-19 OF JUNE 2022
Day 1 – Friday June 17, 2022
8:30-18:30
Registration opens
8:45-9:00
Welcome
University authorities
Francesco Frati (Rector of the University of Siena)
International authorities
Daniela Caporossi (President SFRR-E)
José Viña (Past President SFRR-I)
Organizing Committee
Giuseppe Valacchi (Chair of the Conference)
Enrique Cadenas (Chair Board of Directors, OCC)
Giovanni E. Mann (President SFRR-I)
Juan Sastre (President-Elect SFRR-E)
Session I
Dissecting H2O2 regulated signal transduction
Chairpersons: Enrique Cadenas and Matthew J. Smit
9:05-9:20
Ana Ledo
(University of Coimbra, Portugal)
In vivo Hydrogen Peroxide Diffusivity Supports Volume Signaling Activity in Brain Tissue
9:20-9:35
Emily Boorman
(Department of Neuroinflammation, Institute of Neurology, University College London and School of Cardiovascular and Metabolic Medicine & Sciences, King’s College London, UK)
Neuronal differentiation blocks NRF2-Notch signaling
9:35-9:50
Laura De Cubas
(Universidad de Pompeu Fabra, Spain)
Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or mitochondrial activity
9:50-10:05
Hamza Yusuf Altun
(Sabanci University, Turkey)
Chemogenetic tools and genetic biosensors in redox biology: probing Hyper7 signals in specific cellular locales
10:05-10:20
Gülşah Sevimli
(Sabanci University, Turkey)
Complexities in live cell NO imaging using genetic biosensors
10:20-10:35
Brandán Pedre Pérez
(KU Leuven,Belgium)
Hydrogen peroxide biosensors with novel photophysical properties
10:35-11:05
Coffee Break
Session II
Altered redox signaling in brain disorders
Chairpersons: Josiane Cillard and Paola Gamba
11:05-11:20
Carlos Henríquez-Olguín
(University of Copenhagen, Denmark)
Role of compartmentalized H2O2 redox signaling in skeletal muscle stress-adaptations
11:20-11:35
Haitham Amal
(The Hebrew University of Jerusalem, Israel)
Nitric oxide: from systems biology to drug targets for autism spectrum disorder
11:35-11:50
Alessandra Pecorelli
(Plants for Human Health Institute, North Carolina State University, Kannapolis, NC)
Mitochondria and Inflammasome involvement in Autism Spectrum Disorder
11:50-12:05
Tawfeeq Shekh-Ahmad
(The Hebrew University of Jerusalem, Israel)
Spatiotemporal expression of ROS sources in epilepsy models
12:05-13:15
Flash talks from selected abstracts
Chairpersons: Pablo Evelson and Mascia Benedusi
13:15-14:15
Lunch
Session III
Redox signaling in inflammation
Chairpersons: Giuseppe Poli and Sergio Rius-Pérez
14:15-14:35
Antonio Zorzano
(Universidad de Barcelona, Spain)
Mitochondrial dysfunction and inflammatory responses in metabolic diseases
14:35-14:50
Michaela Sochorová
(Medical University of Vienna, Austria)
Metabolism and oxidative modification of lipids in senescence of cutaneous cells
14:50-15:05
Sergio Rius-Pérez
(Universidad de Valencia, Spain)
p53 drives necroptosis through mitochondrial reactive oxygen species
15:05-15:20
Virginia Solar Fernandez
(University Roma Tre, Italy)
Spreading cell resilience to apoptosis throughout oxidative stress-induced protein discharge in the extracellular media
15:20-15:35
Camila Portugal
(Universidade do Porto, Portugal)
The consequences of the ascorbate transporter SVCT2 internalization in Microglia for Alzheimer’s Disease
15:35-15:50
Jana Raupbach
(German Institute Human Nutrition Potsdam-Rehbruecke)
Dietary glycation compounds and their (anti?)-inflammatory actions
15:50-16:05
Domenico Sergi
(University of Ferrara, Italy)
Long-chain saturated fatty acids at the interface between mitochondrial dysfunction and OxInflammation: implications for metabolic health
16:05-16:35
Coffee Break
Session IV
NRF2 regulated redox signaling
Chairpersons: Niki Chondrogianni and Cristina Mas-Bargue
16:35-16:55
Ron Kohen
(Hebrew University of Jerusalem, Israel)
Nrf2-keap1 Pathway Role in Cutaneous Redox maintenance; Biological, Environmental and Chemical activators
16:55-17:10
Sarah J. Chapple
(King’s College London, UK)
Consequences for Nrf2 redox modulation in adverse pregnancy
17:10-17:25
Matthew J. Smith
(King’s College London, UK)
Metallomic profiling of coronary endothelial cells adapted to physiological normoxia: implications of Nrf2 signalling
17:25-17:40
Vanja Pekovic-Vaughan
(University of Liverpool, UK)
A novel role for an antioxidant transcription factor Nrf2 as a transcriptional repressor of the circadian molecular clock
17:40-17:55
Nathan Siddall
(King’s College London, UK)
Neurovascular protection afforded by the NRF2 activator sulforaphane in ischaemic stroke
17:55-18:10
Ana I Rojo
(Autonomous Universidad Madrid, Spain)
Redox, mitochondrial and NRF2 imbalance are present in C9ORF72-related amyotrophic lateral sclerosis
18:10-18:25
Fan Yang
(King's College London, UK)
Influence of zinc on human coronary artery smooth muscle cells under hypoxia-reoxygenation: implications for Nrf2 redox signaling
18:25-18:40
Francesco Bellanti
(Department of Medical and Surgical Sciences, University of Foggia, Italy)
NRF2 modulation of liver regeneration
20:30
Speakers Dinner
Accademia dei Rozzi – Sala della Suvera
Day 2 – Saturday June 18, 2022
Session V
Mitochondrial redox dynamics
Chairpersons: João Laranjinha and Pablo Hernansanz-Agustín
9:30-9:50
Alberto Sanz
(University of Glasgow, United Kingdom)
ROS signalling requires uninterrupted electron flow and is lost during ageing
9:50-10:05
Pablo Hernansanz-Agustín
(Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Spain)
Na+ controls hypoxic redox signaling by the mitochondrial respiratory chain
10:05-10:20
Rubén Quintana-Cabrera
(Universidad de Salamanca, Spain)
Control of bioenergetics and ROS levels by mitochondrial cristae
10:20-10:35
Jorge Oliveira
(University of Porto, Portugal)
Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice
10:35-10:50
Andrea Irazoki
(Universidad de Barcelona, Spain)
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging
10:50-11:05
Gabriele Baj
(University of Trieste, Italy)
Redox imbalance in RTT syndrome: the mitochondrial morphology and dynamic readouts in an in vitro model.
11:05-11:20
Ilaria Sorrentino
(San Raffaele Hospital, Italy)
Interorganellar redox signalling via AQP11
11:20- 11:50
Coffee Break
Session VI
Redox messengers in health and diseases
Chairpersons: Monica Galleano and
11:50-12:05
Cátia Lourenço Marques
(University of Coimbra, Portugal)
Restoring nitric oxide-mediated neurovascular and cognitive function by dietary nitrate
12:05-12:20
Paola Gamba
(University of Torino, Italy)
The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease
12:20-12:35
Luke Gamon
(University of Copenhagen, Denmark)
Iodide as a potential therapeutic in atherosclerosis
12:35- 12:50
Bárbara S Rocha
(University of Coimbra, Portugal)
May dietary nitrate fuel gut microbiota metabolism? Minding the gap between redox signalling and inter-kingdom communication
12:50-14:00
Group photo
Lunch
Session VII
Effects of environmental pollutants on redox signaling
Chairpersons: Henry J Forman and Francesca Ferrara
14:00-14:15
Marin Kuntic
(University Medical Center Mainz, Germany)
Impact of e-cigarette vaping and shisha smoking on cardiovascular health with focus on oxidative damage and inflammatory reactions
14:15-14:30
Francesca Ferrara
(University of Ferrara, Italy)
Inflammasome activation by Tropospheric Ozone
14:30-14:45
Giorgia Innamorati
(ENEA, Italy)
Effects of the electromagnetic fields (EMFs) on cellular redox homeostasis
14:45-15:00
Timoteo Marchini
(University of Freiburg, Germany)
Chronic exposure to polluted urban air aggravates myocardial infarction by impairing cardiac mitochondrial function and dynamics
15:00-15:15
Danielle Mello
(University of Western Brittany/Ifremer)
Antioxidant and immune responses in bivalves under toxicant stress: insights for biomedical and environmental research
15:15-16:00
Flash talks from selected abstracts
Chairpersons: Silvia Alvarez and Gabriele Baj
16:00-16:20
Coffee Break
Session VIII
Protein Post-Translational Modifications and aging
Chairpersons: Thomas Michel and Eduardo Fuentes-Lemus
16:20-16:40
Fulvio Ursini
(University of Padova, Italy)
PHGPx: 40 years later and ferroptosis
16:40-16:55
Eduardo Fuentes-Lemus
(University of Copenhagen, Denmark)
Do microdomains and biological interfaces modulate protein oxidation and peroxidation?
16:55-17:10
Sandra Anjo
(University of Coimbra, Portugal)
oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening
17:10-17:25
Cristina Mas-Bargues
(Universidad de Valencia, Spain)
Extracellular vesicles and redox modulation in aging
17:25-17:40
Juan Diego Hernández Camacho
(Universidad Pablo de Olavide, Seville, Spain)
Metabolism as modulator of mitochondrial disease
17:40-17:55
Vittoria Cicaloni
(Toscana Life Sciences, Italy)
Proteomics analysis for Redox Biology investigation: basic principles and future perspectives
17:55-18:10
Anna Gioran
(National Hellenic Research Foundation, Greece)
Proteasome activation causes mild mitochondrial defects in C. elegans; Is this the link to lifespan extension?
18:10-18:25
Fabio Marcheggiani
(Polytechnic University of Marche, Italy)
Decoding Coenzyme Q poor tissue bioavailability: New approaches for an old challenge
20:00
Dinner and Awards
Chiostro Piccolomini in San Francesco, Università di Siena
Day 3 – Sunday June 19, 2022
Session IX
From fellowship to publishing: suggestions from the Editors
9:30-9:50
Anthony Newman
(Publisher, Applied Biochemistry Journals ELSEVIER, The Boulevard, Kidlington, Oxford OX5 1GB, UK)
9:50-10:05
Warpsinski Gabriela
(Research Advisor at British Heart Foundation, King's College, London, England, UK)
British Heart Foundation Fellowship Opportunities in the UK
10:05-10:45
Meet the editors:
Kelvin Davies
(Editor in Chief of “Free Radicals in Biology & Medicine”)
Alfonso Pompella
(Editor in Chief of “Advances in Redox Research”)
Henry J Forman
(Editor in Chief of “Archives in Biochemistry and Biophysics”)
Giovanni E. Mann
(Review Editor of “Free Radicals in Biology & Medicine”)
10:45-11:00
Coffee Break
Session X
Redox regulation in physical excercise
Chairpersons: José Viña and Nikos V Margaritelis
11:00-11:20
Malcolm J. Jackson
(Univesity of Liverpool, UK)
Hydrogen peroxide as a signal for skeletal muscle adaptations to exercise: What do concentrations tell us about potential mechanisms?
11:20-11:40
Daniela Caporossi
(University of Rome Foro Italico, Italy)
Redox homeostasis in systemic adaptation to health-enhancing exercise
11:40-11:55
Nikos V Margaritelis
(Aristotle University of Thessaloniki, Greece)
Antioxidant supplementation, redox deficiencies and exercise performance: a falsification design
11:55-12:10
Ivan Dimauro
(University of Rome Foro Italico, Italy)
Exercise, redox homeostasis and the epigenetic landscape?
12:10-13:00
Flash talks from selected abstracts
Chairpersons: Florian Gruber and Carlo Cervellati
13:00-14:00
Lunch
Session XI
Festschrift for Professor Giuseppe Poli
14:00-14:15
Opening
Giuseppe Valacchi, Giovanni E. Mann, Juan Sastre, Enrique Cadenas
Chairpersons: Matilde Maiorino and Kelvin Davies
14:15-14:40
José Viña
(Universidad de Valencia, Spain)
Redox medicine - from AIDS to Alzheimer’s
14:40-15:05
Juan Sastre
(Universidad de Valencia, Spain)
Redox signaling in inflammation
15:05 -15:30
Giovanni E. Mann
(King’s College London, UK)
Defining physiological normoxia in cell biology to improve clinical translation
15:30-16:00
Coffee Break
Chairpersons: Bato Korac and Luca Tiano
16:00-16:25
Patricia Oteiza
(University of California Davis, USA)
NADPH oxidase 1 in intestinal physiology and pathology
16:25-16:50
Clare Hawkins
(University of Copenhagen, Denmark)
Hypochlorous acid-mediated modification of proteins and its consequences
16.50-17:15
Alfonso Pompella
(University of Pisa, Italy)
Glutathione depletion and lipid peroxidation - ferroptosis reloaded
17:15-17:30
“Mario Comporti Lecture”
Chairperson: Giuseppe Valacchi and César Fraga
17:30-18:00
Giuseppe Poli
(University of Turin, Italy)
Cholesterol oxidation products: from the redox bench to industry
18:00-18:30
Closing Remarks
Giuseppe Valacchi (Chair of the Conference),
Enrique Cadenas (Chair Board of Directors, OCC),
Giovanni E. Mann (President SFRR-I),
Juan Sastre (President-Elect SFRR-E)
