Scientific Program

THE FUTURE OF REDOX BIOLOGY
SIENA 17-19 OF JUNE 2022

Day 1 – Friday June 17, 2022

8:30-18:30

Registration opens

8:45-9:00

Welcome

University authorities

Francesco Frati (Rector of the University of Siena)

International authorities

Daniela Caporossi (President SFRR-E)
José Viña (Past President SFRR-I)

Organizing Committee

Giuseppe Valacchi (Chair of the Conference)
Enrique Cadenas (Chair Board of Directors, OCC)
Giovanni E. Mann (President SFRR-I)
Juan Sastre (President-Elect SFRR-E)

Session I

Dissecting H2O2 regulated signal transduction

Chairpersons: Enrique Cadenas and  Matthew J. Smit

9:05-9:20

Ana Ledo
(University of Coimbra, Portugal)
In vivo Hydrogen Peroxide Diffusivity Supports Volume Signaling Activity in Brain Tissue

9:20-9:35

Emily Boorman
(Department of Neuroinflammation, Institute of Neurology, University College London and School of Cardiovascular and Metabolic Medicine & Sciences, King’s College London, UK)
Neuronal differentiation blocks NRF2-Notch signaling

9:35-9:50

Laura De Cubas
(Universidad de Pompeu Fabra, Spain)
Monitoring cytosolic H2O2 fluctuations arising from altered plasma membrane gradients or mitochondrial activity

9:50-10:05

Hamza Yusuf Altun
(Sabanci University, Turkey)
Chemogenetic tools and genetic biosensors in redox biology: probing Hyper7 signals in specific cellular locales

10:05-10:20

Gülşah Sevimli
(Sabanci University, Turkey)
Complexities in live cell NO imaging using genetic biosensors

10:20-10:35

Brandán Pedre Pérez
(KU Leuven,Belgium)
Hydrogen peroxide biosensors with novel photophysical properties

10:35-11:05

Coffee Break

Session II

Altered redox signaling in brain disorders

Chairpersons: Josiane Cillard and Paola Gamba

11:05-11:20

Carlos Henríquez-Olguín
(University of Copenhagen, Denmark)
Role of compartmentalized H2O2 redox signaling in skeletal muscle stress-adaptations

11:20-11:35

Haitham Amal
(The Hebrew University of Jerusalem, Israel)
Nitric oxide: from systems biology to drug targets for autism spectrum disorder

11:35-11:50

Alessandra Pecorelli
(Plants for Human Health Institute, North Carolina State University, Kannapolis, NC)
Mitochondria and Inflammasome involvement in Autism Spectrum Disorder

11:50-12:05

Tawfeeq Shekh-Ahmad
(The Hebrew University of Jerusalem, Israel)
Spatiotemporal expression of ROS sources in epilepsy models

12:05-13:15

Flash talks from selected abstracts

Chairpersons: Pablo Evelson and Mascia Benedusi

13:15-14:15

Lunch

Session III

Redox signaling in inflammation

Chairpersons: Giuseppe Poli and Sergio Rius-Pérez

14:15-14:35

Antonio Zorzano
(Universidad de Barcelona, Spain)
Mitochondrial dysfunction and inflammatory responses in metabolic diseases

14:35-14:50

Michaela Sochorová
(Medical University of Vienna, Austria)
Metabolism and oxidative modification of lipids in senescence of cutaneous cells

14:50-15:05

Sergio Rius-Pérez
(Universidad de Valencia, Spain)
p53 drives necroptosis through mitochondrial reactive oxygen species

15:05-15:20

Virginia Solar Fernandez
(University Roma Tre, Italy)
Spreading cell resilience to apoptosis throughout oxidative stress-induced protein discharge in the extracellular media

15:20-15:35

Camila Portugal
(Universidade do Porto, Portugal)
The consequences of the ascorbate transporter SVCT2 internalization in Microglia for Alzheimer’s Disease

15:35-15:50

Jana Raupbach
(German Institute Human Nutrition Potsdam-Rehbruecke)
Dietary glycation compounds and their (anti?)-inflammatory actions

15:50-16:05

Domenico Sergi
(University of Ferrara, Italy)
Long-chain saturated fatty acids at the interface between mitochondrial dysfunction and OxInflammation: implications for metabolic health

16:05-16:35

Coffee Break

Session IV

NRF2 regulated redox signaling

Chairpersons: Niki Chondrogianni and  Cristina Mas-Bargue

16:35-16:55

Ron Kohen
(Hebrew University of Jerusalem, Israel)
Nrf2-keap1 Pathway Role in Cutaneous Redox maintenance; Biological, Environmental and Chemical activators

16:55-17:10

Sarah J. Chapple​
(King’s College London, UK)
Consequences for Nrf2 redox modulation in adverse pregnancy

17:10-17:25

Matthew J. Smith
(King’s College London, UK)
Metallomic profiling of coronary endothelial cells adapted to physiological normoxia: implications of Nrf2 signalling

17:25-17:40

Vanja Pekovic-Vaughan
(University of Liverpool, UK)
A novel role for an antioxidant transcription factor Nrf2 as a transcriptional repressor of the circadian molecular clock

17:40-17:55

Nathan Siddall
(King’s College London, UK)
Neurovascular protection afforded by the NRF2 activator sulforaphane in ischaemic stroke

17:55-18:10

Ana I Rojo
(Autonomous Universidad Madrid, Spain)
Redox, mitochondrial and NRF2 imbalance are present in C9ORF72-related amyotrophic lateral sclerosis

18:10-18:25

Fan Yang
(King's College London, UK)
Influence of zinc on human coronary artery smooth muscle cells under hypoxia-reoxygenation: implications for Nrf2 redox signaling

18:25-18:40

Francesco Bellanti
(Department of Medical and Surgical Sciences, University of Foggia, Italy)
NRF2 modulation of liver regeneration

20:30

Speakers Dinner

Accademia dei Rozzi – Sala della Suvera

Day 2 – Saturday June 18, 2022

Session V

Mitochondrial redox dynamics

Chairpersons: João Laranjinha and Pablo Hernansanz-Agustín

9:30-9:50

Alberto Sanz
(University of Glasgow, United Kingdom)
ROS signalling requires uninterrupted electron flow and is lost during ageing

9:50-10:05

Pablo Hernansanz-Agustín
(Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III CNIC, Spain)
Na+ controls hypoxic redox signaling by the mitochondrial respiratory chain

10:05-10:20

Rubén Quintana-Cabrera
(Universidad de Salamanca, Spain)
Control of bioenergetics and ROS levels by mitochondrial cristae

10:20-10:35

Jorge Oliveira
(University of Porto, Portugal)
Redox signalling and proteostasis in neurodegeneration: In vivo effects of the mitochondria-targeted antioxidant MitoQ in Huntington's disease mice

10:35-10:50

Andrea Irazoki
(Universidad de Barcelona, Spain)
Coordination of mitochondrial and lysosomal homeostasis mitigates inflammation and muscle atrophy during aging

10:50-11:05

Gabriele Baj
(University of Trieste, Italy)
Redox imbalance in RTT syndrome: the mitochondrial morphology and dynamic readouts in an in vitro model.

11:05-11:20

Ilaria Sorrentino
(San Raffaele Hospital, Italy)
Interorganellar redox signalling via AQP11

11:20- 11:50

Coffee Break

Session VI

Redox messengers in health and diseases

Chairpersons: Monica Galleano and Bárbara S Rocha

11:50-12:05

Cátia Lourenço Marques
(University of Coimbra, Portugal)
Restoring nitric oxide-mediated neurovascular and cognitive function by dietary nitrate

12:05-12:20

Paola Gamba
(University of Torino, Italy)
The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer's Disease

12:20-12:35

Luke Gamon
(University of Copenhagen, Denmark)
Iodide as a potential therapeutic in atherosclerosis

12:35- 12:50

Bárbara S Rocha
(University of Coimbra, Portugal)
May dietary nitrate fuel gut microbiota metabolism? Minding the gap between redox signalling and inter-kingdom communication

12:50-14:00

Group photo
Lunch

Session VII

Effects of environmental pollutants on redox signaling

Chairpersons: Henry J Forman and Francesca Ferrara

14:00-14:15

Marin Kuntic
(University Medical Center Mainz, Germany)
Impact of e-cigarette vaping and shisha smoking on cardiovascular health with focus on oxidative damage and inflammatory reactions

14:15-14:30

Francesca Ferrara
(University of Ferrara, Italy)
Inflammasome activation by Tropospheric Ozone

14:30-14:45

Giorgia Innamorati
(ENEA, Italy)
Effects of the electromagnetic fields (EMFs) on cellular redox homeostasis

14:45-15:00

Timoteo Marchini
(University of Freiburg, Germany)
Chronic exposure to polluted urban air aggravates myocardial infarction by impairing cardiac mitochondrial function and dynamics

15:00-15:15

Danielle Mello
(University of Western Brittany/Ifremer)
Antioxidant and immune responses in bivalves under toxicant stress: insights for biomedical and environmental research

15:15-16:00

Flash talks from selected abstracts

Chairpersons: Silvia Alvarez and Gabriele Baj

16:00-16:20

Coffee Break

Session VIII

Protein Post-Translational Modifications and aging

Chairpersons: Thomas Michel and Eduardo Fuentes-Lemus

16:20-16:40

Fulvio Ursini
(University of Padova, Italy)
PHGPx: 40 years later and ferroptosis

16:40-16:55

Eduardo Fuentes-Lemus
(University of Copenhagen, Denmark)
Do microdomains and biological interfaces modulate protein oxidation and peroxidation?

16:55-17:10

Sandra Anjo
(University of Coimbra, Portugal)
oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening

17:10-17:25

Cristina Mas-Bargues
(Universidad de Valencia, Spain)
Extracellular vesicles and redox modulation in aging

17:25-17:40

Juan Diego Hernández Camacho
(Universidad Pablo de Olavide, Seville, Spain)
Metabolism as modulator of mitochondrial disease

17:40-17:55

Vittoria Cicaloni
(Toscana Life Sciences, Italy)
Proteomics analysis for Redox Biology investigation: basic principles and future perspectives

17:55-18:10

Anna Gioran
(National Hellenic Research Foundation, Greece)
Proteasome activation causes mild mitochondrial defects in C. elegans; Is this the link to lifespan extension?

18:10-18:25

Fabio Marcheggiani
(Polytechnic University of Marche, Italy)
Decoding Coenzyme Q poor tissue bioavailability: New approaches for an old challenge

20:00

Dinner and Awards

Chiostro Piccolomini in San Francesco, Università di Siena

Day 3 – Sunday June 19, 2022

Session IX

From fellowship to publishing: suggestions from the Editors

9:30-9:50

Anthony Newman
(Publisher, Applied Biochemistry Journals ELSEVIER, The Boulevard, Kidlington, Oxford OX5 1GB, UK)

9:50-10:05

Warpsinski Gabriela
(Research Advisor at British Heart Foundation, King's College, London, England, UK)
British Heart Foundation Fellowship Opportunities in the UK

10:05-10:45

Meet the editors:
Kelvin Davies
(Editor in Chief of “Free Radicals in Biology & Medicine”)
Alfonso Pompella
(Editor in Chief of “Advances in Redox Research”)
Henry J Forman
(Editor in Chief of “Archives in Biochemistry and Biophysics”)
Giovanni E. Mann
(Review Editor of “Free Radicals in Biology & Medicine”)

10:45-11:00

Coffee Break

Session X

Redox regulation in physical excercise

Chairpersons: José Viña and Nikos V Margaritelis

11:00-11:20

Malcolm J. Jackson
(Univesity of Liverpool, UK)
Hydrogen peroxide as a signal for skeletal muscle adaptations to exercise: What do concentrations tell us about potential mechanisms?

11:20-11:40

Daniela Caporossi
(University of Rome Foro Italico, Italy)
Redox homeostasis in systemic adaptation to health-enhancing exercise

11:40-11:55

Nikos V Margaritelis
(Aristotle University of Thessaloniki, Greece)
Antioxidant supplementation, redox deficiencies and exercise performance: a falsification design

11:55-12:10

Ivan Dimauro
(University of Rome Foro Italico, Italy)
Exercise, redox homeostasis and the epigenetic landscape?

12:10-13:00

Flash talks from selected abstracts

Chairpersons: Florian Gruber and Carlo Cervellati

13:00-14:00

Lunch

Session XI

Festschrift for Professor Giuseppe Poli

14:00-14:15

Opening

Giuseppe Valacchi, Giovanni E. Mann, Juan Sastre, Enrique Cadenas

Chairpersons: Matilde Maiorino and Kelvin Davies

14:15-14:40

José Viña
(Universidad de Valencia, Spain)
Redox medicine - from AIDS to Alzheimer’s

14:40-15:05

Juan Sastre
(Universidad de Valencia, Spain)
Redox signaling in inflammation

15:05 -15:30

Giovanni E. Mann
(King’s College London, UK)
Defining physiological normoxia in cell biology to improve clinical translation

15:30-16:00

Coffee Break

Chairpersons: Bato Korac and Luca Tiano

16:00-16:25

Patricia Oteiza
(University of California Davis, USA)
NADPH oxidase 1 in intestinal physiology and pathology

16:25-16:50

Clare Hawkins
(University of Copenhagen, Denmark)
Hypochlorous acid-mediated modification of proteins and its consequences

16.50-17:15

Alfonso Pompella
(University of Pisa, Italy)
Glutathione depletion and lipid peroxidation - ferroptosis reloaded

17:15-17:30

“Mario Comporti Lecture”

Chairperson: Giuseppe Valacchi and César Fraga

17:30-18:00

Giuseppe Poli
(University of Turin, Italy)
Cholesterol oxidation products: from the redox bench to industry

18:00-18:30

Closing Remarks

Giuseppe Valacchi (Chair of the Conference),
Enrique Cadenas (Chair Board of Directors, OCC),
Giovanni E. Mann (President SFRR-I),
Juan Sastre (President-Elect SFRR-E)